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KMID : 0378019800230110103
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New Medical Journal
1980 Volume.23 No. 11 p.103 ~ p.108
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The Effect of Dextran Sulfate on Experimental Infection with Mycobacterium tuberculosis H_(3^(v)), R_(v) in Mice
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Abstract
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Mycobacterium tuberculosis is an intracelular parasite like Mycobacterium leprae, Mycobacterium lepraemurium, Listeria monocytogenes, etc. In tuberculosis, the host resistance depends mainly upon cell mediated immunity.
The effect of dextran sulfate (DS500) on immune responses has been shown to be suppressive or stimulatory on humoral immunity, mitogenic for B-cell, enhancing antigen uptake in spleen, suppressive antigen uptake in liver, and impaired resistance to, L. monocytogenes infaction in mice.
Especially, DS 500 is known to be capable of suppressing antibacterial resistance in Listeria monocytogenes infection.
It was observed the effect of DS 500 on the resistance to tubercle bacilli infection in mice.
In the group that DS 500 (50mg/kg) was given intraperitoneally 24hours before innoculation of tubercle bacilli it showed no effect in growth of tubercle bacilli in spleen and lung, but in the group of animals to which DS 500 (50mg/kg) was administered every other day after tubercle bacilli infection, bacterial growth was much more enhanced in spleen and liver than that in control, and the mortality rate due to tubercle bacilli infection was increased in the experimental group treated with DS 500 every other day.
This might suggest that repeated administration of DS 500 could suppress the host defence mechanism against tubercle bacilli infection.
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KEYWORD
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